ACCESSION: MSBNK-Athens_Univ-AU280804
RECORD_TITLE: Drospirenone; LC-ESI-QTOF; MS2; CE: 40 eV; R=35000; [M+H]+
DATE: 2019.05.31
AUTHORS: Nikiforos Alygizakis, Katerina Galani, Nikolaos Thomaidis, University of Athens
LICENSE: CC BY
COPYRIGHT: Copyright (C) 2019 Department of Chemistry, University of Athens
COMMENT: CONFIDENCE standard compound
COMMENT: INTERNAL_ID 2808
CH$NAME: Drospirenone
CH$NAME: (1R,2R,4R,10R,11S,14S,15S,16S,18S,19S)-10,14-dimethylspiro[hexacyclo[9.8.0.02,4.05,10.014,19.016,18]nonadec-5-ene-15,5`-oxolane]-2`,7-dione
CH$COMPOUND_CLASS: N/A; Environmental Standard
CH$FORMULA: C24H30O3
CH$EXACT_MASS: 366.2194948
CH$SMILES: [H][C@@]12[C@@H]3C[C@@H]3[C@@]3(CCC(=O)O3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@H]2C[C@H]2C2=CC(=O)CC[C@]12C
CH$IUPAC: InChI=1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1
CH$LINK: CAS
67392-87-4
CH$LINK: CHEBI
50838
CH$LINK: KEGG
D03917
CH$LINK: PUBCHEM
CID:68873
CH$LINK: INCHIKEY
METQSPRSQINEEU-HXCATZOESA-N
CH$LINK: CHEMSPIDER
62105
CH$LINK: COMPTOX
DTXSID7046465
AC$INSTRUMENT: Bruker maXis Impact
AC$INSTRUMENT_TYPE: LC-ESI-QTOF
AC$MASS_SPECTROMETRY: MS_TYPE MS2
AC$MASS_SPECTROMETRY: ION_MODE POSITIVE
AC$MASS_SPECTROMETRY: IONIZATION ESI
AC$MASS_SPECTROMETRY: FRAGMENTATION_MODE CID
AC$MASS_SPECTROMETRY: COLLISION_ENERGY 40 eV
AC$MASS_SPECTROMETRY: RESOLUTION 35000
AC$CHROMATOGRAPHY: COLUMN_NAME Acclaim RSLC C18 2.2um, 2.1x100mm, Thermo
AC$CHROMATOGRAPHY: FLOW_GRADIENT 99/1 at 0-1 min, 61/39 at 3 min, 0.1/99.9 at 14-16 min, 99/1 at 16.1-20 min
AC$CHROMATOGRAPHY: FLOW_RATE 200 uL/min at 0-3 min, 400 uL/min at 14 min, 480 uL/min at 16-19 min, 200 uL/min at 19.1-20 min
AC$CHROMATOGRAPHY: RETENTION_TIME 9.543 min
AC$CHROMATOGRAPHY: SOLVENT A 90:10 water:methanol with 0.01% formic acid and 5mM ammonium formate
AC$CHROMATOGRAPHY: SOLVENT B methanol with 0.01% formic acid and 5mM ammonium formate
MS$FOCUSED_ION: BASE_PEAK 367.2263
MS$FOCUSED_ION: PRECURSOR_M/Z 367.2268
MS$FOCUSED_ION: PRECURSOR_TYPE [M+H]+
MS$DATA_PROCESSING: RECALIBRATE identity on assigned fragments and MS1
MS$DATA_PROCESSING: WHOLE RMassBank 2.10.1
PK$SPLASH: splash10-0a5a-0920000000-25e17416637e3e73f781
PK$ANNOTATION: m/z tentative_formula formula_count mass error(ppm)
111.0429 C6H7O2+ 1 111.0441 -10.77
115.0534 C9H7+ 1 115.0542 -6.98
116.0613 C9H8+ 1 116.0621 -6.65
117.0689 C9H9+ 1 117.0699 -8.61
118.0729 C8[13]CH9+ 1 118.0738 -7.6
119.0845 C9H11+ 1 119.0855 -8.53
120.0874 C8[13]CH11+ 1 120.0894 -17.16
121.0638 C8H9O+ 1 121.0648 -8.22
121.1004 C9H13+ 1 121.1012 -6.26
122.0672 C7[13]CH9O+ 1 122.0687 -12.39
123.0795 C8H11O+ 1 123.0804 -7.63
124.0834 C7[13]CH11O+ 1 124.0843 -7.7
125.0586 C7H9O2+ 1 125.0597 -9.05
127.0531 C10H7+ 1 127.0542 -8.71
127.0734 C7H11O2+ 1 127.0754 -15.25
128.0607 C10H8+ 1 128.0621 -10.54
129.0685 C10H9+ 1 129.0699 -10.82
130.0746 C10H10+ 1 130.0777 -24.04
131.0845 C10H11+ 1 131.0855 -7.6
132.0562 C9H8O+ 1 132.057 -5.5
132.0881 C9[13]CH11+ 1 132.0894 -10.25
133.0636 C9H9O+ 1 133.0648 -9.02
133.0999 C10H13+ 1 133.1012 -9.48
134.1041 C9[13]CH13+ 1 134.1051 -7.19
135.0793 C9H11O+ 1 135.0804 -8.72
135.1155 C10H15+ 1 135.1168 -9.95
136.1226 C10H16+ 1 136.1247 -14.92
137.0588 C8H9O2+ 1 137.0597 -6.58
137.0946 C9H13O+ 1 137.0961 -11.03
138.0988 C8[13]CH13O+ 1 138.1 -8.85
139.076 C8H11O2+ 1 139.0754 4.45
141.0685 C11H9+ 1 141.0699 -9.46
142.0758 C11H10+ 1 142.0777 -13.46
143.0842 C11H11+ 1 143.0855 -9.56
144.0563 C10H8O+ 1 144.057 -4.77
144.0894 C10[13]CH11+ 1 144.0894 -0.15
145.0635 C10H9O+ 1 145.0648 -8.91
145.0999 C11H13+ 1 145.1012 -8.56
146.0702 C10H10O+ 1 146.0726 -16.27
146.1037 C10[13]CH13+ 1 146.1051 -9.47
147.079 C10H11O+ 1 147.0804 -9.6
147.1151 C11H15+ 1 147.1168 -11.56
148.0835 C9[13]CH11O+ 1 148.0843 -5.86
148.1205 C10[13]CH15+ 1 148.1207 -1.71
149.0945 C10H13O+ 1 149.0961 -10.69
150.0979 C9[13]CH13O+ 1 150.1 -13.74
151.0741 C9H11O2+ 1 151.0754 -8.29
151.1099 C10H15O+ 1 151.1117 -12.41
152.0614 C12H8+ 1 152.0621 -4.55
153.0683 C12H9+ 1 153.0699 -10.58
153.09 C9H13O2+ 1 153.091 -6.45
154.0764 C12H10+ 1 154.0777 -8.34
155.0838 C12H11+ 1 155.0855 -10.83
156.091 C12H12+ 1 156.0934 -14.96
157.0998 C12H13+ 1 157.1012 -8.9
158.0704 C11H10O+ 1 158.0726 -14.14
158.1042 C11[13]CH13+ 1 158.1051 -5.7
159.0789 C11H11O+ 1 159.0804 -9.76
159.1156 C12H15+ 1 159.1168 -7.81
160.0841 C10[13]CH11O+ 1 160.0843 -1.61
160.1188 C11[13]CH15+ 1 160.1207 -11.96
161.0948 C11H13O+ 1 161.0961 -8
161.1307 C12H17+ 1 161.1325 -11.32
162.0993 C10[13]CH13O+ 1 162.1 -4.22
162.1352 C11[13]CH17+ 1 162.1364 -7.41
163.074 C10H11O2+ 1 163.0754 -8.42
163.1104 C11H15O+ 1 163.1117 -8.09
164.083 C9[13]CH11O2+ 1 164.0793 22.51
165.0682 C13H9+ 1 165.0699 -10.1
165.0893 C10H13O2+ 1 165.091 -10.1
166.0755 C13H10+ 1 166.0777 -13.08
167.0835 C13H11+ 1 167.0855 -12.21
168.0911 C13H12+ 1 168.0934 -13.25
169.0995 C13H13+ 1 169.1012 -9.68
170.1056 C12[13]CH13+ 1 170.1051 2.88
171.0782 C12H11O+ 1 171.0804 -13.2
171.1154 C13H15+ 1 171.1168 -8.4
172.1197 C12[13]CH15+ 1 172.1207 -6.16
173.0945 C12H13O+ 1 173.0961 -9.14
173.1309 C13H17+ 1 173.1325 -8.83
174.0984 C11[13]CH13O+ 1 174.1 -9.26
174.1354 C12[13]CH17+ 1 174.1364 -5.88
175.0733 C11H11O2+ 1 175.0754 -11.91
175.1104 C12H15O+ 1 175.1117 -7.7
175.151 C13H19+ 1 175.1481 16.37
176.1138 C11[13]CH15O+ 1 176.1156 -10.45
177.0895 C11H13O2+ 1 177.091 -8.62
178.0766 C14H10+ 1 178.0777 -6.31
178.0929 C10[13]CH13O2+ 1 178.0949 -11.53
179.0838 C14H11+ 1 179.0855 -9.68
179.1048 C11H15O2+ 1 179.1067 -10.35
180.0916 C14H12+ 1 180.0934 -9.48
181.0993 C14H13+ 1 181.1012 -10.12
182.1062 C14H14+ 1 182.109 -15.22
183.0789 C13H11O+ 1 183.0804 -8.68
183.1155 C14H15+ 1 183.1168 -6.99
184.0881 C13H12O+ 1 184.0883 -0.83
184.1204 C13[13]CH15+ 1 184.1207 -1.93
185.094 C13H13O+ 1 185.0961 -11.03
185.131 C14H17+ 1 185.1325 -7.75
186.1008 C13H14O+ 1 186.1039 -16.73
186.1349 C13[13]CH17+ 1 186.1364 -7.81
187.1109 C13H15O+ 1 187.1117 -4.44
187.1453 C14H19+ 1 187.1481 -15.3
188.1147 C12[13]CH15O+ 1 188.1156 -4.81
189.0897 C12H13O2+ 1 189.091 -6.79
189.126 C13H17O+ 1 189.1274 -7.12
190.0966 C12H14O2+ 1 190.0988 -11.55
190.131 C12[13]CH17O+ 1 190.1313 -1.67
191.0843 C15H11+ 1 191.0855 -6.47
191.1049 C12H15O2+ 1 191.1067 -9.02
192.0927 C15H12+ 1 192.0934 -3.28
193.0993 C15H13+ 1 193.1012 -9.53
193.1189 C12H17O2+ 1 193.1223 -17.85
194.107 C15H14+ 1 194.109 -10.2
195.1153 C15H15+ 1 195.1168 -7.92
196.0844 C14H12O+ 1 196.0883 -19.66
196.1205 C14[13]CH15+ 1 196.1207 -1.31
197.0954 C14H13O+ 1 197.0961 -3.64
197.131 C15H17+ 1 197.1325 -7.69
198.1002 C14H14O+ 1 198.1039 -18.63
198.1348 C14[13]CH17+ 1 198.1364 -8.22
199.1105 C14H15O+ 1 199.1117 -6.47
199.1468 C15H19+ 1 199.1481 -6.47
200.1157 C13[13]CH15O+ 1 200.1156 0.24
200.1516 C14[13]CH19+ 1 200.152 -1.98
201.0904 C13H13O2+ 1 201.091 -2.83
201.1261 C14H17O+ 1 201.1274 -6.43
201.1623 C15H21+ 1 201.1638 -7.46
202.0987 C13H14O2+ 1 202.0988 -0.5
202.13 C13[13]CH17O+ 1 202.1313 -6.24
203.0855 C16H11+ 1 203.0855 0.08
203.1053 C13H15O2+ 1 203.1067 -6.73
203.1413 C14H19O+ 1 203.143 -8.78
204.093 C16H12+ 1 204.0934 -1.5
204.1126 C12[13]CH15O2+ 1 204.1106 10.22
205.1 C16H13+ 1 205.1012 -5.62
205.12 C13H17O2+ 1 205.1223 -11.08
206.1072 C16H14+ 1 206.109 -8.79
207.1148 C16H15+ 1 207.1168 -9.55
208.1223 C16H16+ 1 208.1247 -11.46
209.0941 C15H13O+ 1 209.0961 -9.62
209.1306 C16H17+ 1 209.1325 -8.96
210.0993 C15H14O+ 1 210.1039 -21.91
210.1363 C15[13]CH17+ 1 210.1364 -0.21
211.1101 C15H15O+ 1 211.1117 -7.79
211.1465 C16H19+ 1 211.1481 -7.8
212.1155 C15H16O+ 1 212.1196 -19.18
212.1508 C15[13]CH19+ 1 212.152 -5.92
213.0895 C14H13O2+ 1 213.091 -6.83
213.1259 C15H17O+ 1 213.1274 -6.82
214.1324 C14[13]CH17O+ 1 214.1313 5.2
215.1047 C14H15O2+ 1 215.1067 -9.26
215.1412 C15H19O+ 1 215.143 -8.44
215.1802 C16H23+ 1 215.1794 3.69
216.1143 C14H16O2+ 1 216.1145 -0.73
216.1442 C14[13]CH19O+ 1 216.1469 -12.73
217.0998 C17H13+ 1 217.1012 -6.48
217.1203 C14H17O2+ 1 217.1223 -9.07
218.1071 C17H14+ 1 218.109 -8.69
218.1251 C13[13]CH17O2+ 1 218.1262 -5.05
219.1142 C17H15+ 1 219.1168 -12.13
219.1361 C14H19O2+ 1 219.138 -8.65
220.1237 C17H16+ 1 220.1247 -4.41
220.1395 C13[13]CH19O2+ 1 220.1419 -10.94
221.1307 C17H17+ 1 221.1325 -8.16
222.1016 C16H14O+ 1 222.1039 -10.63
222.1368 C16[13]CH17+ 1 222.1364 1.87
223.1112 C16H15O+ 1 223.1117 -2.44
223.1472 C17H19+ 1 223.1481 -4.35
224.1168 C16H16O+ 1 224.1196 -12.52
224.1513 C16[13]CH19+ 1 224.152 -3.21
225.1258 C16H17O+ 1 225.1274 -7.08
225.1636 C17H21+ 1 225.1638 -0.97
226.1641 C16[13]CH21+ 1 226.1677 -15.77
227.1067 C15H15O2+ 1 227.1067 0.03
227.1422 C16H19O+ 1 227.143 -3.86
227.1793 C17H23+ 1 227.1794 -0.56
228.1117 C15H16O2+ 1 228.1145 -12.26
228.1476 C15[13]CH19O+ 1 228.1469 3
229.1212 C15H17O2+ 1 229.1223 -4.67
229.1597 C16H21O+ 1 229.1587 4.39
230.1088 C18H14+ 1 230.109 -0.99
230.1272 C14[13]CH17O2+ 1 230.1262 4.34
231.1169 C18H15+ 1 231.1168 0.37
231.1366 C15H19O2+ 1 231.138 -5.85
232.1242 C18H16+ 1 232.1247 -2.15
232.1402 C14[13]CH19O2+ 1 232.1419 -7.28
233.1314 C18H17+ 1 233.1325 -4.55
234.1 C17H14O+ 1 234.1039 -16.56
234.1364 C18H18+ 1 234.1403 -16.51
235.111 C17H15O+ 1 235.1117 -3.15
235.1465 C18H19+ 1 235.1481 -6.77
236.115 C17H16O+ 1 236.1196 -19.48
236.1517 C17[13]CH19+ 1 236.152 -1.3
237.1249 C17H17O+ 1 237.1274 -10.34
237.1624 C18H21+ 1 237.1638 -6.01
238.1319 C17H18O+ 1 238.1352 -13.73
238.1672 C18H22+ 1 238.1716 -18.62
239.104 C16H15O2+ 1 239.1067 -11.29
239.1417 C17H19O+ 1 239.143 -5.48
239.1764 C18H23+ 1 239.1794 -12.57
240.1496 C17H20O+ 1 240.1509 -5.39
241.1215 C16H17O2+ 1 241.1223 -3.38
241.1585 C17H21O+ 1 241.1587 -0.63
242.1265 C16H18O2+ 1 242.1301 -15.18
242.1619 C16[13]CH21O+ 1 242.1626 -2.67
243.1129 C19H15+ 1 243.1168 -15.96
243.1371 C16H19O2+ 1 243.138 -3.44
244.121 C19H16+ 1 244.1247 -14.99
244.1422 C15[13]CH19O2+ 1 244.1419 1.34
245.0936 C18H13O+ 1 245.0961 -10.22
245.1332 C19H17+ 1 245.1325 2.94
245.1535 C16H21O2+ 1 245.1536 -0.37
246.1393 C19H18+ 1 246.1403 -4.16
246.1607 C15[13]CH21O2+ 1 246.1575 12.8
247.1474 C19H19+ 1 247.1481 -3.09
248.1195 C18H16O+ 1 248.1196 -0.1
248.1527 C19H20+ 1 248.156 -13.27
249.1276 C18H17O+ 1 249.1274 0.87
249.1617 C19H21+ 1 249.1638 -8.26
250.1329 C18H18O+ 1 250.1352 -9.39
250.169 C19H22+ 1 250.1716 -10.23
251.1417 C18H19O+ 1 251.143 -5.36
251.1789 C19H23+ 1 251.1794 -1.9
252.1472 C18H20O+ 1 252.1509 -14.5
252.1829 C18[13]CH23+ 1 252.1833 -1.86
253.1218 C17H17O2+ 1 253.1223 -1.96
253.1571 C18H21O+ 1 253.1587 -6.25
254.125 C17H18O2+ 1 254.1301 -20.37
254.1615 C18H22O+ 1 254.1665 -19.84
255.1355 C17H19O2+ 1 255.138 -9.49
255.1728 C18H23O+ 1 255.1743 -6.09
257.1314 C20H17+ 1 257.1325 -4.14
257.1529 C17H21O2+ 1 257.1536 -2.79
258.1385 C20H18+ 1 258.1403 -6.86
258.1574 C16[13]CH21O2+ 1 258.1575 -0.5
259.1468 C20H19+ 1 259.1481 -5.13
260.155 C20H20+ 1 260.156 -3.65
261.1252 C19H17O+ 1 261.1274 -8.27
261.1635 C20H21+ 1 261.1638 -0.89
262.1674 C20H22+ 1 262.1716 -15.98
263.1431 C19H19O+ 1 263.143 0.33
263.177 C20H23+ 1 263.1794 -9.31
264.1493 C19H20O+ 1 264.1509 -6.08
264.1846 C20H24+ 1 264.1873 -10.16
265.123 C18H17O2+ 1 265.1223 2.53
265.1577 C19H21O+ 1 265.1587 -3.68
265.1943 C20H25+ 1 265.1951 -3.07
266.1623 C19H22O+ 1 266.1665 -15.99
267.1362 C18H19O2+ 1 267.138 -6.59
267.1729 C19H23O+ 1 267.1743 -5.42
268.1432 C18H20O2+ 1 268.1458 -9.52
269.1516 C18H21O2+ 1 269.1536 -7.44
269.1903 C19H25O+ 1 269.19 1.09
270.1558 C18H22O2+ 1 270.1614 -20.78
271.1489 C21H19+ 1 271.1481 2.78
271.1666 C18H23O2+ 1 271.1693 -9.9
272.1498 C21H20+ 1 272.156 -22.62
273.1595 C21H21+ 1 273.1638 -15.56
274.1674 C21H22+ 1 274.1716 -15.45
275.1399 C20H19O+ 1 275.143 -11.49
275.1777 C21H23+ 1 275.1794 -6.35
276.1454 C20H20O+ 1 276.1509 -19.69
276.1858 C21H24+ 1 276.1873 -5.17
277.1576 C20H21O+ 1 277.1587 -4.08
277.1917 C21H25+ 1 277.1951 -12.28
278.1602 C19[13]CH21O+ 1 278.1626 -8.6
279.1374 C19H19O2+ 1 279.138 -1.97
279.1734 C20H23O+ 1 279.1743 -3.22
279.2088 C21H27+ 1 279.2107 -6.77
280.177 C20H24O+ 1 280.1822 -18.37
281.1518 C19H21O2+ 1 281.1536 -6.5
282.1577 C18[13]CH21O2+ 1 282.1575 0.85
283.167 C19H23O2+ 1 283.1693 -7.98
285.1637 C22H21+ 1 285.1638 -0.22
287.1816 C22H23+ 1 287.1794 7.62
288.1827 C22H24+ 1 288.1873 -15.81
289.1576 C21H21O+ 1 289.1587 -3.85
289.1944 C22H25+ 1 289.1951 -2.3
290.1954 C21[13]CH25+ 1 290.199 -12.31
291.1713 C21H23O+ 1 291.1743 -10.56
292.181 C21H24O+ 1 292.1822 -4.14
293.1547 C20H21O2+ 1 293.1536 3.57
293.1904 C21H25O+ 1 293.19 1.44
294.1614 C20H22O2+ 1 294.1614 -0.16
294.1951 C21H26O+ 1 294.1978 -9.27
295.1683 C20H23O2+ 1 295.1693 -3.37
296.1759 C20H24O2+ 1 296.1771 -3.92
297.1495 C19H21O3+ 1 297.1485 3.16
297.1816 C20H25O2+ 1 297.1849 -11.04
298.1761 C23H22+ 1 298.1716 15.08
303.1746 C22H23O+ 1 303.1743 0.84
303.2093 C23H27+ 1 303.2107 -4.64
305.1895 C22H25O+ 1 305.19 -1.66
306.1913 C22H26O+ 1 306.1978 -21.16
307.1683 C21H23O2+ 1 307.1693 -2.99
307.2042 C22H27O+ 1 307.2056 -4.53
308.1739 C21H24O2+ 1 308.1771 -10.46
308.2052 C21[13]CH27O+ 1 308.2095 -14.08
309.1817 C21H25O2+ 1 309.1849 -10.52
310.187 C21H26O2+ 1 310.1927 -18.55
313.1917 C24H25+ 1 313.1951 -10.75
320.1779 C22H24O2+ 1 320.1771 2.4
321.1848 C22H25O2+ 1 321.1849 -0.22
321.219 C23H29O+ 1 321.2213 -7.24
322.2239 C23H30O+ 1 322.2291 -16.3
323.2013 C22H27O2+ 1 323.2006 2.32
325.2173 C22H29O2+ 1 325.2162 3.28
331.204 C24H27O+ 1 331.2056 -4.81
334.19 C23H26O2+ 1 334.1927 -8.2
349.2139 C24H29O2+ 1 349.2162 -6.69
350.2198 C24H30O2+ 1 350.224 -12.17
352.2005 C23H28O3+ 1 352.2033 -8.03
367.2262 C24H31O3+ 1 367.2268 -1.49
368.2295 C23[13]CH31O3+ 1 368.2307 -3.18
PK$NUM_PEAK: 316
PK$PEAK: m/z int. rel.int.
111.0429 492 8
115.0534 7572 130
116.0613 1856 32
117.0689 10888 188
118.0729 1532 26
119.0845 17976 310
120.0874 2300 39
121.0638 10660 184
121.1004 2680 46
122.0672 1052 18
123.0795 14244 245
124.0834 1088 18
125.0586 1444 24
127.0531 1148 19
127.0734 384 6
128.0607 14348 247
129.0685 23984 414
130.0746 6132 105
131.0845 57852 999
132.0562 544 9
132.0881 6080 104
133.0636 4752 82
133.0999 14924 257
134.1041 1544 26
135.0793 21836 377
135.1155 2164 37
136.1226 412 7
137.0588 684 11
137.0946 3028 52
138.0988 448 7
139.076 428 7
141.0685 11960 206
142.0758 12684 219
143.0842 49776 859
144.0563 896 15
144.0894 7900 136
145.0635 3812 65
145.0999 32580 562
146.0702 1044 18
146.1037 3712 64
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//